Viewing snapshots of the cellular landscape of diseased tissue through the lens of a statistician

Abstract: The human body comprises over 37 trillion cells with diverse forms and functions, which can exhibit dynamic changes based on their environmental context. Understanding the spatial interactions between cells and changes in their state within the tissue microenvironment is crucial to comprehending the development of human diseases. State-of-the-art technologies can now deeply phenotype cells in their native environment, providing a high-throughput means of identifying spatially related changes in their function. In this talk, I will illustrate how established statistical tools can be bent in novel ways to produce new perspectives of diseased tissue. By doing this I hope to motivate discussions on how these complex cellular systems could be quantified with unique, robust or mathematically rigorous approaches.

Mathematics

Audience: researchers in the topic

OneSchool Seminar

Series comments: This seminar series aims to facilitate sharing and learning about the research of our fellow staff members. Early and mid-career researchers will present a broader context of their work which should be accessible and relatable to the entire School community. Seminars will be held in-person, followed by a friendly gathering and refreshments in the SMRI common room or out on the terrace (weather permitting). Everyone is warmly invited.